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The UC Berkeley Center for the Science of Psychedelics BCSP The action did depend on 5-HT2A receptor activation, however, because systemic administration of ritanserin, a 5-HT2A antagonist, blocked the effect. Based on the dopaminergic nature of the LSD90 cue, it was speculated that these animals might manifest behaviors that resembled core symptoms of schizophrenia. Thus, these animals were further investigated by Marona-Lewicka et al. to determine whether chronic Psychedelic treatment of rats with LSD might represent a new animal model of schizophrenia. Drug discrimination followed the methods described in their earlier studies and used a two-lever FR10 food-reinforced paradigm. In a subsequent study, Bernasconi et al. carried out electrical neuroimaging analyses on visual evoked potentials in response to facial expressions under placebo and psilocybin treatment. To study the role of 5-HT2 receptors in the response, they carried out experiments in which they administered either ...